"Obviously you've played a lot of extraordinary women. What was the most challenging woman you ever played?" Wintour innocently asks Streep in the video, posted on Thursday.
"Oh, I should say [you]!" Streep laughed, referencing her Wintour-inspired character from The Devil Wears Prada for a brief moment, before Wintour shut her down.
"No, no, we're not going to go there, Meryl," she replied.
"That wasn't, anyway," Streep conceded. "That was fun."